Medicube
PDRN Pink Collagen Glow Jelly Mist Serum
Key ingredient: Salmon PDRN + Collagen
For users curious about PDRN (salmon DNA) — the regenerative active that defined modern Korean dermatology clinics — without booking a Rejuran injection, the Medicube PDRN Pink Collagen Glow Jelly Mist Serum is the most-marketed K-beauty topical entry into the category and a sensible starting point for skin in its 30s+.
The ingredient story
Hero ingredient
PDRN (Polydeoxyribonucleotide) + Hydrolyzed Collagen + Peptides
Concentration
Medicube does not publish exact PDRN percentage on the label (uncommon in the topical PDRN category — most brands don't). The product is part of Medicube's "PDRN Pink" line, where PDRN is the hero across multiple formats.
Deep-dive
Read the full guide →How it works
PDRN works through two distinct mechanisms: (1) Activates the adenosine A2A receptor on skin cells, triggering fibroblast proliferation, collagen synthesis, and reduced inflammation. (2) The salvage pathway — DNA fragments are broken into nucleotides that surrounding cells absorb as raw material for their own DNA repair. The Jelly Mist format pairs PDRN with hydrolyzed collagen and peptides for stacked regenerative signalling.
What the evidence shows
Injectable PDRN (Rejuran) has the strongest clinical evidence — 5-year post-marketing surveillance covering 300,000+ Korean prescriptions with no significant adverse events. Topical PDRN delivers a fraction of the injectable effect due to molecular size barriers, but well-formulated products like the Medicube line show measurable elasticity and tone improvement over 8–12 weeks. See /ingredients/pdrn for the full mechanism story including topical vs injectable comparison.
Skip if you have a known fish or shellfish allergy (PDRN is purified to remove proteins, but trace contamination is theoretically possible). Vegan routines should pick a different regenerative active — there is no plant-derived equivalent of PDRN.
The brand
Philosophy
“Korean dermatology clinic technologies (PDRN, RF, microneedling) translated into at-home consumer products.”
Medicube was founded in 2015 with an explicit thesis: the gap between Korean clinic-grade procedures (PDRN injections, RF devices, polynucleotide treatments) and at-home consumer skincare was unnecessarily large, and Korean indie brands had room to translate the clinic-grade actives into consumer products. The PDRN Pink Collagen line launched in 2023 and became the K-beauty consumer entry point into the PDRN category. Medicube also makes the popular AGE-R RF home-use device. The brand sits in the upper-mid K-beauty pricing tier — premium for K-beauty (£25–40 range), value for what it delivers compared to a Western "growth factor" serum at £80+.
Where this fits in your routine
Routine step
Mist serum — apply after toner/essence, before moisturiser. Can also be used as a midday hydration top-up.
Morning: cleanse → toner → essence → Medicube PDRN → moisturiser → SPF Evening: double cleanse → toner → essence → Medicube PDRN → moisturiser → facial oil (optional)
Post-procedure use: Medicube PDRN Pink is one of the products Korean dermatologists recommend for at-home maintenance between Rejuran injection appointments. It does not replace the procedure but extends the recovery window.
Best after 30. Below 30, PDRN's regenerative benefits are largely wasted on skin that already turns over rapidly. The product is technically safe for any age, but the cost-to-benefit improves with age.
Pregnancy: topical PDRN is generally considered low-risk but data are limited. Consult a clinician if uncertain.
Pairs especially well with
SKIN1004 Madagascar Centella Ampoule — centella calms while PDRN repairs — classic post-procedure or anti-ageing combination
Dr.Jart+ Ceramidin Cream — PDRN serum first to trigger regenerative signalling, ceramide cream to seal and rebuild the barrier
Numbuzin No.5+ Vitamin-Niacinamide Serum — use in opposite routines (PDRN PM, brightening AM) to avoid overloading any single mechanism
Full ingredients
Free from
Full INCI ingredient list (manufacturer)
Water, Polydeoxyribonucleotide, Glycerin, Methylpropanediol, Niacinamide, Hydrolyzed Collagen, Hyaluronic Acid, Sodium Hyaluronate, Panthenol, Adenosine, Allantoin, Acetyl Hexapeptide-8, Copper Tripeptide-1, Centella Asiatica Extract, Bifida Ferment Lysate, Sodium PCA, 1,2-Hexanediol, Carbomer, Tromethamine, Phenoxyethanol, Disodium EDTA, Tocopherol
What real users say
“I have used Rejuran (the injectable) for 3 years. This Medicube product is the at-home maintenance product that actually extends my appointment intervals from 4 weeks to 6 weeks. Genuine clinical-feeling effect.”
— Reddit r/SkincareAddiction, 2024
“I am 38 and the elasticity in my under-eye area visibly improved after 10 weeks. Not dramatic but real and durable.”
— TikTok review with 1.4M views, @kbeauty_emma
“Pink packaging looks more gimmicky than the formula warrants. This is a genuine clinical-grade active product, not a TikTok aesthetic product.”
— r/AsianBeauty, 2024
Texture / feel
Light jelly-mist consistency that sprays as a fine mist and absorbs into a satin finish with no tackiness. Very faint herbal scent (no added fragrance). The mist format means you can also use it midday over makeup as a hydration top-up.
Buying authentic
Verified UK retailers
Counterfeit warning
Medicube PDRN packaging features a distinctive bright pink tube with crisp printing. Counterfeit Medicube PDRN products are widespread on Amazon UK third-party sellers and Vinted. Buy from listed authorised retailers only.
This page was last reviewed on 2026-05-19. We update product storytelling when formulation, retailer availability, or evidence changes meaningfully.
About this product
Anti-ageing mist serum with salmon PDRN for boosting elasticity, fading dark spots and delivering a youthful collagen glow on the go.
Best for these skin types
Concerns addressed
Peptides, retinol, and collagen-boosting ingredients restore bounce. Protect existing collagen with daily SPF.
